A. Immunohistochemical markers are useful for dating severe traumatic brain injury. B. Glial Fibrillary Acidic Protein (GFPA) highlights how astrocytes change their morphology(hypertrophy) and rise their number (hyperplasia) during the inflammatory process.C. Blood Brain Barrier (BBB) undergoes changes after trauma that are able to be seen thanks to GFPA.D. CD68 allows to see how macrophages migrate to brain parenchima and the behaviour of microglia after an insult.
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Romero Tirado (2022) studied this question.
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