Key result
Specific vaccine adjuvants stimulating innate immunity can broaden the antibody repertoire induced by vaccines, potentially aiding in the control of variable pathogens.
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Design
Editorial
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Manipulating vaccine adjuvants to broaden the antibody repertoire may offer a strategy to combat pathogens that evade the immune system through antigen variation.
In this Perspective, we discuss two papers that show that the breadth of the antibody response to vaccines could be manipulated by the use of particular vaccine adjuvants that stimulate innate immune mechanisms. The ability to increase the repertoire of antibodies induced by a vaccine may help to control variable pathogens that alter their exposed antigens to evade the immune system.
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Pollard et al. (2011) studied this question. Specific vaccine adjuvants stimulating innate immunity can broaden the antibody repertoire induced by vaccines, potentially aiding in the control of variable pathogens.
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