This article discusses genomic rearrangement processes that shape the primary antibody repertoire for diverse immune responses.
The ability to generate a diverse immune response depends on the somatic assembly of genes that encode the antigen-binding portions of immunoglobulin molecules. In this article, we discuss the mechanism and control of these genomic rearrangement events and how aspects of this process are involved in generating the primary antibody repertoire.
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Alt et al. (1987) studied this question.
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