Key result
Peripheral neuropathy in primary Sjögren Syndrome is significantly associated with reduced plasma vitamin B12 and total serum protein levels compared to patients without neuropathy.
Why the study?
Does low vitamin B12 concentration predict peripheral neuropathy in patients with primary Sjögren Syndrome?
Case-Control (n=96)
No
Does low vitamin B12 concentration predict peripheral neuropathy in patients with primary Sjögren Syndrome?
Low B12 levels were associated with PN in pSS but lacked predictive value; leaves open whether supplementation prevents neuropathy.
Prognostic factors for peripheral nervous system (PNS) manifestations in primary Sjögren Syndrome (pSS) are essential for predicting and preventing disease-related disability. Given the established relationship between vitamin B12 deficiency and pSS, we aimed to investigate the predictive value of low B12 concentration for Sjögren's induced peripheral neuropathy (PN).
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Ancuta et al. (2022) conducted a case-control in Primary Sjögren Syndrome (n=96). Peripheral neuropathy vs. No peripheral neuropathy was evaluated on Plasma vitamin B12 concentration (ng/L) (95% CI -310.93 to -2.07, p=0.047). Peripheral neuropathy in primary Sjögren Syndrome is significantly associated with reduced plasma vitamin B12 and total serum protein levels compared to patients without neuropathy.
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