Why the study?
Does left atrial appendage closure provide similar reductions in stroke and bleeding in octogenarians compared to younger patients?
Does left atrial appendage closure provide similar reductions in stroke and bleeding in octogenarians compared to younger patients?
Left atrial appendage closure is safe and reduces stroke and bleeding events in octogenarians, although the magnitude of benefit is smaller than in younger patients.
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LAAC was associated with stroke reduction in octogenarians; leaves open whether net benefit matches younger patients in randomized trials.
OBJECTIVES: Whether left atrial appendage closure (LAAC) in octogenarians yield similar net clinical benefit compared to younger patients, was the purpose of the present study. METHODS: Two real-world LAAC registries, enrolling 744 consecutive Amplatzer and Watchman patients from 2009 to 2018, were retrospectively analyzed. Compared to the anticipated stroke rate, the observed rate decreased by 41% in octogenarians and 53% in non-octogenarians. The observed bleeding rate was reduced by 10% octogenarians and 41% non-octogenarians. CONCLUSIONS: LAAC can be performed with similar safety in octogenarians as compared to younger patients. On the long-term, it both reduces stroke and bleeding events, although to a lesser extent than in non-octogenarians.
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Mohrez et al. (2021) studied this question.
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