Key result
Perioperative statin therapy is supported by robust evidence in cardiac surgery, but its role in noncardiac surgery remains ambiguous due to concerns of scientific misconduct in pivotal studies.
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This editorial highlights the established role of statins in cardiac surgery while noting the ambiguity of their benefit in noncardiac surgery due to concerns over scientific misconduct in prior pivotal studies.
Perioperative statin therapy has come to represent a cornerstone of risk reduction for millions of patients who undergo cardiac and noncardiac surgeries. While large-scale, robust, randomized controlled studies support the use of statins in cardiac surgery, their role in noncardiac surgery has become ambiguous following concerns regarding scientific misconduct in many pivotal studies. In this edition of the Expert Opinion on Pharmacotherapy, Irwin et al. comprehensively summarize the evidence for perioperative statin treatment. The authors add to this review by providing expert opinions regarding the state of the science and future paths for research and enquiry.
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Fallouh et al. (2013) conducted an editorial in Cardiac and noncardiac surgeries. Perioperative statin therapy was evaluated. Perioperative statin therapy is supported by robust evidence in cardiac surgery, but its role in noncardiac surgery remains ambiguous due to concerns of scientific misconduct in pivotal studies.
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