Key result
Right atrial anatomical remodeling is linked to early non-valvular AF recurrence after successful catheter ablation.
Why the study?
Atrial fibrillation leads to progressive electrical, contractile, and structural remodeling, but remodeling outside the left atrium has received little attention.
This review highlights the progression of atrial fibrillation-induced remodeling from electrical to structural changes, noting a lack of attention to remodeling outside the left atrium.
May inform early rhythm-control timing in AF; leaves open prospective trials on remodeling-targeted strategies.
trial fibrillation (AF) is one of the most common arrhythmias observed in clinical practice.It is well known that paroxysms of AF become longer, that AF becomes refractory to pharmacological rhythm-control treatment, and that the electrical defibrillation threshold is gradually elevated.The most accepted concept explaining these clinical phenomena is so-called remodeling.There is a body of evidence with respect to the time course of AF-induced remodeling: that is, that electrical remodeling affecting the expression and function of various cardiac ion channels occurs at first, then, contractile remodeling follows, and, finally, structural remodeling takes place leading to left atrial (LA) mechanical dysfunction and enlargement.1 LA is undoubtedly the most accepted site of remodeling caused by AF, whereas remodeling observed in areas other than the LA has drawn little attention so far.
No takes yet. Share an insight, caveat, or question.
Toru Maruyama (2012) conducted an editorial in Atrial Fibrillation. Right atrial anatomical remodeling is an independent predictor of early recurrence of non-valvular atrial fibrillation after successful radiofrequency ablation.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: