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Kv7.1 homology models fail to accurately predict channel blocker potency in virtual screening.
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Goncearenco et al. (2007) studied Long QT Syndrome (LQTS). Homology modeling and virtual screening was evaluated on Correlation between experimental pIC50s and docking scores. Homology models of the human Kv7.1 channel were validated against mutagenesis data, but virtual screening for blocker potency performed poorly, likely due to conformational state changes during gating.
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