Key result
Specific enterovirus serotypes are linked to a ~90% rate of meningitis versus other strains.
Why the study?
The association of clinical presentation, laboratory findings, and virus serotypes with the presence of meningitis in hospitalized infants with enterovirus infection was unclear.
Population
108 hospitalized infants with enteroviral infections
Comparison
Infants with meningitis vs infants without meningitis
Design
Observational study
Authors
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Serotype-specific meningitis associations in enterovirus-infected infants warrant clinical awareness; hypothesis-generating and requires prospective confirmation.
Observational (n=108)
Absolute Event Rate: 90% vs 4%
The frequency of meningitis among hospitalized infants with enterovirus infection is serotype dependent and often unsuspected clinically.
Dagan et al. (1988) conducted an observational in Enterovirus infection (n=108). Specific enterovirus serotypes (Echoviruses 30, 11, and coxsackie virus B) vs. Echoviruses 18, 24, and 25 was evaluated on Presence of meningitis. Specific enterovirus serotypes (echoviruses 30 and 11, coxsackie virus B) were associated with meningitis in 90% of cases, compared to 4% for echoviruses 18, 24, and 25.
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