Key result
A high degree of antigenic conservation was found among H1 swine influenza viruses, with a dominant variant (52 of 54 isolates) showing no amino acid substitutions relative to a reference strain.
H1N1 swine influenza viruses show a high degree of antigenic and genetic conservation in their haemagglutinin.
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High antigenic conservation in swine H1 viruses supports stable vaccine antigen selection; leaves open human surveillance implications.
Noble et al. (1993) studied H1N1 swine influenza (n=54). Haemagglutination inhibition assays and PCR sequencing was evaluated on Antigenic conservation and amino acid substitutions in the HA1 region. A high degree of antigenic conservation was found among H1 swine influenza viruses, with a dominant variant (52 of 54 isolates) showing no amino acid substitutions relative to a reference strain.
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