Key result
Reduced endothelial HIF-1β/ARNT in diabetes is linked to endothelial dysfunction, heart failure, and mortality.
Why the study?
The specific role of ARNT in the diabetic heart and its contribution to endothelial dysfunction in diabetic cardiovascular disease is unknown.
Investigating the role of endothelial ARNT in diabetic cardiovascular disease could lead to new therapies for treatment or prevention.
Aryl hydrocarbon receptor nuclear translocator (ARNT), also known as hypoxia-inducible factor-1 beta (HIF-1β), is a transcription factor that functions as a master regulator of glucose homeostasis. We have previously demonstrated that ARNT expression is highest in the heart, where it is required for maintaining normal cardiac metabolism and cardiac function. Diabetes is associated with a loss of ARNT, although the specific role of ARNT in the diabetic heart is still unknown. Diabetes is also characterized by endothelial dysfunction. Thus, investigating the role of endothelial ARNT in diabetic cardiovascular disease could lead to new therapies for treatment or prevention.
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Su et al. (2017) conducted an editorial in Diabetes and cardiovascular disease. HIF-1β/ARNT was evaluated. Endothelial HIF-1β/ARNT is critical in maintaining endothelial function, and its reduced levels in diabetes may contribute to heart failure and increased mortality.
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