SUMMARY The presence of digestive group allotypes and of the corresponding natural alloantibodies was investigated in 367 rabbits, using the immunofluorescent method, the haemagglutination inhibition test, and absorption studies with digestive mucosa extracts. The rabbit digestive group system appeared to be restricted to the reciprocal presence of one antigen only, the A antigen, cross reacting with human blood group A substance, and of the corresponding circulating anti-A natural alloantibodies. Two hundred seventy-nine rabbits (76%) were found to have the A antigen in their digestive secretions, but no circulating anti-A antibodies (A(+) rabbits). In 88 rabbits (24%) the A antigen could not be evidenced, while specific anti-A alloantibodies were naturally present in their serum (A(-) rabbits). The A antigen could not be evidenced in any tissue different from the digestive mucosa, nor in the red cells of the A(+) rabbits.
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Zweibaum et al. (1973) studied this question.
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