Metal-catalyzed hydroaminomethylations of styrenes, which take place by CH bond activation, can be achieved in the presence of the catalyst [Ind2TiMe2] (Ind=η5-indenyl). Corresponding reactions of 1-alkenes with N-methylanilines performed at temperatures between 80 °C and 105 °C usually take place with regioselectivities of better than 99:1 in favor of the branched product.
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Kubiak et al. (2010) studied this question.
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