Key result
Autologous vein graft-coated stents achieve TIMI 3 flow in acute MI, yielding ~3.0 mm MLD.
Why the study?
Recent studies indicated a potential role for stents in treating thrombus-containing coronary artery lesions, but clinical application data were limited.
Does an autologous vein graft-coated stent improve angiographic and clinical outcomes in patients with acute myocardial infarction and thrombus-containing coronary artery lesions?
Case Report (n=10)
Does an autologous vein graft-coated stent improve angiographic and clinical outcomes in patients with acute myocardial infarction and thrombus-containing coronary artery lesions?
Autologous vein graft-coated stents demonstrated procedural success and favorable short-term angiographic outcomes in a small series of patients with acute myocardial infarction.
Feasibility shown in small AMI series; leaves open whether autologous vein graft-coated stents improve outcomes over standard stenting.
Recent studies have shown that stents may have a potential role in the treatment of thrombus-containing lesions. We report on the application of an autologous vein graft-coated stent (AVGCS) as the primary therapeutic modality for acute myocardial infarction in 10 patients. AVGCS delivery and deployment were successful and uneventful. Mean minimal lumen diameter and TIMI trial flow grade increased significantly (from 0.04 +/- 0.09 mm pre-AVGCS to 3.02 +/- 0.32 mm post-AVGCS, and from 10 patients with flow grade 0-1 pre-AVGCS to 10 patients with flow grade 3 post-AVGCS, respectively). Ten-day angiogram revealed maintenance of the immediate results. Nine patients had a negative exercise stress test 2 mo post-AVGCS, and at a mean follow-up of 30 +/- 7 weeks, all 9 were symptom-free. One patient, 3 wk after implantation and while being hospitalized for hypovolemic shock, developed recurrent infarction. These favorable preliminary outcomes suggest that AVGCS may play a useful role in the treatment of thrombus-containing lesions.
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Stefanadis et al. (1997) conducted a case report in Acute myocardial infarction with thrombus-containing coronary artery lesions (n=10). Autologous vein graft-coated stent (AVGCS) was evaluated on Mean minimal lumen diameter and TIMI trial flow grade. Autologous vein graft-coated stents increased mean minimal lumen diameter to 3.02 mm and achieved TIMI grade 3 flow in 10 patients with acute myocardial infarction.
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