Key result
Indicator-dilution reliably measures regurgitant flow regardless of residual volume or mixing degree.
Why the study?
The conditions required for valid measurement of regurgitant flow across incompetent valves by indicator-dilution were not established.
Population
Functioning mechanical model of the heart
Comparison
Indicator-dilution measurement of regurgitant flow across incompetent valves
Design
Theoretical analysis and experimental demonstration using mechanical heart model
Authors
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Confirms indicator-dilution validity under specified conditions in animal models; leaves open translation to clinical regurgitation assessment.
This study establishes the theoretical and practical conditions required for valid measurement of valvular regurgitation using indicator-dilution techniques.
LACY et al. (1959) studied Incompetent valves. Indicator-dilution measurement was evaluated on Validity of regurgitant flow measurement. Measurement of regurgitant flow by indicator-dilution is valid regardless of residual volume size or mixing degree, provided a representative sample of indicator concentration is obtained.
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