Key result
Novel ultrasound molecular imaging may improve early detection and risk stratification in atherosclerosis.
Why the study?
Recent advances in understanding atherosclerosis pathophysiology have created the need for better non-invasive imaging of vascular phenotype.
Novel ultrasound imaging techniques, including molecular imaging, offer promising non-invasive methods for early detection and risk assessment of atherosclerosis.
May enable better non-invasive plaque phenotyping by ultrasound; leaves open prospective outcome validation before adoption.
Recent advances in our understanding of the pathophysiological mechanisms of atherosclerosis have created the need for better non-invasive imaging of vascular phenotype. Ultrasound is widely available, inexpensive, and well suited for high-throughput screening in populations that are at risk for atherosclerosis. Novel ultrasonic approaches for the diagnosis of vascular changes in atherosclerosis include (1) assessment of plaque composition by evaluation of the backscattering properties of tissue, (2) assessment of the changes in arterial wall biomechanics, (3) assessment of plaque neovascularization, and (4) molecular imaging of vascular phenotype changes on a subcellular level. It is thought that such new imaging methodologies will lead to earlier detection of atherosclerosis, and better assessment of the risk for aggressive disease progression. Novel therapies for atherosclerosis will undoubtedly become available within the next decades, and non-invasive imaging techniques will be needed for cost-efficient application of existing and new drugs.
No takes yet. Share an insight, caveat, or question.
Beat A. Kaufmann (2009) conducted a review in Atherosclerosis. Ultrasound molecular imaging was evaluated. Novel ultrasonic approaches, including molecular imaging, may lead to earlier detection of atherosclerosis and better assessment of the risk for aggressive disease progression.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: