Key result
Myocarditis affects ~3% of patients with antisynthetase syndrome, with most achieving full recovery.
Why the study?
Myocardial involvement in antisynthetase syndrome is poorly described, necessitating characterization of myocarditis prevalence and features in this condition.
What is the prevalence, clinical presentation, and prognosis of myocarditis in patients with antisynthetase syndrome?
Population
352 antisynthetase syndrome patients from a registry
Design
Retrospective observational cohort study
Follow-up
Median 11 months (range 0-84)
Authors
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Myocarditis warrants consideration in aSS with troponin elevation; hypothesis-generating and should not yet change practice.
Observational (n=352)
What is the prevalence, clinical presentation, and prognosis of myocarditis in patients with antisynthetase syndrome?
Myocarditis is a severe but relatively rare (3.4%) manifestation in active antisynthetase syndrome that generally has a good prognosis with immunosuppressive therapy.
Dieval et al. (2015) conducted an observational in Antisynthetase syndrome (n=352). Antisynthetase syndrome was evaluated on Prevalence of myocarditis. In a registry of 352 patients with antisynthetase syndrome, the prevalence of myocarditis was 3.4%, with 75% of affected patients recovering after a median follow-up of 11 months.
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