Key result
Familial Mediterranean fever was associated with significantly higher mean pulse wave velocity (7.31 vs 6.47 m/s) and arterial stiffness frequency (72.9% vs 28%) compared to healthy controls, particularly in patients with M694V mutations.
Why the study?
The influence of MEFV mutations on arterial stiffness in patients with Familial Mediterranean fever was unclear.
Do MEFV mutations influence arterial stiffness in patients with Familial Mediterranean fever?
Case-Control (n=120)
No
Do MEFV mutations influence arterial stiffness in patients with Familial Mediterranean fever?
Absolute Event Rate: 7.31% vs 6.47%
p-value: p=<0.001
Patients with Familial Mediterranean fever, particularly those with M694V mutations, exhibit increased arterial stiffness and may require closer monitoring for early atherosclerosis.
M694V carriers may face higher CV risk warranting closer monitoring; leaves open whether mutation-guided screening improves outcomes in FMF.
Background: Pulse wave velocity (PWV) is the most used technique to evaluate the arterial elasticity, which is an early indicator of atherosclerosis. We aimed to evaluate if MEFV Mutations influence arterial stiffness in patients with Familial Mediterranean fever (FMF) Methods: 70 patients diagnosed with FMF and 50 age-and sex-matched controls were included in the study. Genetic analysis of the patients was performed. After the measurement of PWV; the presence of AS was determined. Results: Mean PWV value and arterial stiffness frequency of FMF patients were significantly higher than the control group (p <0.001, p <0.001) respectively. In addition, FMF patients with M694Vmutations had higher PWV values and arterial stiffness frequency than those with other mutations. (p=0.045), (p=0.001). There were no differences within all genetic mutation types in terms of arterial stiffness frequency.Conclusions: As a result, due to subclinical inflammation in FMF patients, they have risk for cardiovascular complications. These patients especially those with M694Vmutations have to be followed more closely because of increased cardiovascular risk and PWV measurements may be a good tool to detect early development of atherosclerosis.
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Ulu et al. (2014) conducted a case-control in Familial Mediterranean fever (n=120). Familial Mediterranean fever and MEFV mutations vs. Healthy controls was evaluated on Mean Pulse Wave Velocity (PWV) in m/s (p=<0.001). Familial Mediterranean fever was associated with significantly higher mean pulse wave velocity (7.31 vs 6.47 m/s) and arterial stiffness frequency (72.9% vs 28%) compared to healthy controls, particularly in patients with M694V mutations.
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