Key result
Obesity linked to ~10-fold higher risk of incident acanthosis nigricans in American Indian children.
Why the study?
The prevalence of acanthosis nigricans and its association with diabetes risk factors among Northern Plains American Indian children was not well characterized.
Cross-Sectional (n=2,520)
Relative Risk: 9.8 (95% CI 4.2–23)
Acanthosis nigricans is prevalent among Northern Plains American Indian children and strongly associated with obesity and other diabetes risk factors, highlighting its utility as a clinical marker for insulin resistance.
May support acanthosis nigricans screening in obese American Indian children; leaves open need for prospective validation before practice change.
The purpose of this study is to present cross-sectional and prospective data on acanthosis nigricans (AN) prevalence in the context of other risk factors for diabetes including high body mass index (BMI), abnormal blood pressure (BP), physical inactivity and family history of diabetes among Northern Plains American Indian (AI) children. Standardized health measures were collected in 2,520 K-12th-grade AI students for AN, BMI, and BP. Data were also collected on family history of diabetes and physical activity. Approximately, 9.7% of the participants were positive for AN. AN was associated with high BMI, abnormal BP, and diabetes family history. Sports participation was inversely associated with AN. Among children measured the prior year, relative risk (and 95% confidence interval [CI]) for obesity and incident AN was 9.8 (4.2-23.0) compared to normal weight. These findings suggest there is utility in measuring this marker of insulin resistance in this at-risk population.
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Brown et al. (2010) conducted a cross-sectional in Acanthosis nigricans and diabetes risk factors (n=2,520). Obesity vs. Normal weight was evaluated on Incident acanthosis nigricans (RR 9.8, 95% CI 4.2-23.0). Obesity was associated with a significantly higher risk of incident acanthosis nigricans compared to normal weight among American Indian children (RR 9.8; 95% CI 4.2-23.0).
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