Key result
Apo A-V SNP3 T/C genotype is linked to ~28% higher triglycerides in type 2 diabetes.
Why the study?
The Apo A-V gene SNP3 polymorphism was associated with triglyceride variation in healthy subjects, but its interaction with lipid profile and CAD in Tunisian type 2 diabetic patients was unclear.
Is the SNP3 polymorphism in the apolipoprotein A-V gene associated with plasma triglyceride levels and coronary artery disease in Tunisian type 2 diabetic patients?
Observational (n=308)
No
Is the SNP3 polymorphism in the apolipoprotein A-V gene associated with plasma triglyceride levels and coronary artery disease in Tunisian type 2 diabetic patients?
Absolute Event Rate: 2.62% vs 2.05%
p-value: p=0.024
The SNP3 polymorphism in the apolipoprotein A-V gene is associated with higher triglyceride levels but not with coronary artery disease in Tunisian patients with type 2 diabetes.
SNP3 heterozygosity was associated with higher triglycerides in Tunisian T2D; hypothesis-generating for CAD risk and should not yet change practice.
BACKGROUND: Apolipoprotein A-V (Apo A-V) gene has recently been identified as a new apolipoprotein involved in triglyceride metabolism. A single nucleotide polymorphism (SNP3) located in the gene promoter (-1131) was associated with triglyceride variation in healthy subjects. In type 2 diabetes the triglyceride level increased compared to healthy subjects. Hypertriglyceridemia is a risk factor for coronary artery disease. We aimed to examine the interaction between SNP3 and lipid profile and coronary artery disease (CAD) in Tunisian type 2 diabetic patients. RESULTS: The genotype frequencies of T/T, T/C and C/C were 0.74, 0.23 and 0.03 respectively in non diabetic subjects, 0.71, 0.25 and 0.04 respectively in type 2 diabetic patients. Triglyceride level was higher in heterozygous genotype (-1131 T/C) of apo A-V (p = 0.024). Heterozygous genotype is more frequent in high triglyceride group (40.9%) than in low triglyceride group (18.8%); p = 0.011. Despite the relation between CAD and hypertriglyceridemia the SNP 3 was not associated with CAD. CONCLUSION: In type 2 diabetic patients SNP3 is associated with triglyceride level, however there was no association between SNP3 and coronary artery disease.
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Châaba et al. (2005) conducted an observational in Type 2 diabetes and coronary artery disease (n=308). SNP3 polymorphism (-1131 T/C) in the apolipoprotein A-V gene vs. T/T genotype (wild type) was evaluated on Plasma triglyceride level (mmol/l) (p=0.024). The heterozygous genotype (T/C) of the apo A-V SNP3 polymorphism was significantly associated with higher plasma triglyceride levels in Tunisian type 2 diabetic patients compared to the T/T genotype.
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