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Two cohorts of 20 patients diagnosed with neoplastic meningitis (NM) with or without encephalopathy were matched with respect to age, sex, primary tumor, and performance status. Median survival was 10 weeks (range 6 to 20 weeks) in the cohort with NM-related encephalopathy compared to 24 weeks (range 8 to 40 weeks) in the cohort without NM-related encephalopathy (p < 0.001). NM-related encephalopathy is a clinical variable that predicts for poor survival in patients with NM.
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Chamberlain et al. (2004) studied this question.
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