Key result
The 1/1 genotype of PS1 1/2 (OR 1.77; 95% CI 1.03-3.04) and I/I genotype of ACE I/D (OR 2.44; 95% CI 1.78-3.35) were significantly associated with increased Alzheimer's disease risk.
Why the study?
Are PS1 1/2, ACE I/D, and LRP C/T polymorphisms associated with an increased risk of Alzheimer's disease in the Chinese population?
Meta-Analysis (n=5,433)
Yes
Are PS1 1/2, ACE I/D, and LRP C/T polymorphisms associated with an increased risk of Alzheimer's disease in the Chinese population?
The 1/1 genotype of the PS1 1/2 polymorphism and the I/I genotype of the ACE I/D polymorphism are significantly associated with an increased risk of Alzheimer's disease in the Chinese population.
PS1 1/1 and ACE I/I genotypes may elevate AD risk in Chinese patients; hypothesis-generating and requires prospective validation before clinical use.
The objective of this study was to assess the associations of presenilin 1 (PS1) 1/2, angiotensin I-converting enzyme (ACE) insertion/deletion (I/D), and low-density lipoprotein receptor-related protein (LRP) C/T polymorphisms with the risk of Alzheimer's disease (AD) in the Chinese population. PS1 1/2, ACE I/D, and LRP C/T, which are commonly investigated polymorphisms, were evaluated to obtain summary estimates regarding their associations with AD. In total, the data from 24 studies (2611 patients with AD and 2822 control subjects from 23 provinces and special districts in China) that were obtained from the Chinese Biomedicine Database, China National Knowledge Infrastructure, PubMed, and Medline were included. Different models (i.e., dominant, recessive, etc.) of these polymorphisms were analyzed using the Cochrane Review Manager. Statistically significant associations among patients with AD for the 1/1 genotype of the PS1 1/2 polymorphism [odds ratio (OR) = 1.77, 95% confidence interval (CI) = 1.03-3.04; P = 0.04] and the I/I genotype of the ACE I/D polymorphism (OR = 2.44, 95%CI = 1.78-3.35; P < 0.01) were identified. Statistically significant associations were also found for the PS1 1/2 polymorphism in both the dominant and recessive genetic models, whereas no association was found for the LRP C/T polymorphism. All studies exhibited heterogeneity (P < 0.05). This meta-analysis suggests that the 1/1 genotype of the PS1 1/2 polymorphism and the I/I genotype of the ACE I/D polymorphism are significantly associated with an increased risk of AD in the Chinese population.
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Zhou et al. (2015) conducted a meta-analysis in Alzheimer's disease (n=5,433). PS1 1/2, ACE I/D, and LRP C/T polymorphisms vs. Control subjects was evaluated on Alzheimer's disease (OR 1.77, 95% CI 1.03-3.04, p=0.04). The 1/1 genotype of PS1 1/2 (OR 1.77; 95% CI 1.03-3.04) and I/I genotype of ACE I/D (OR 2.44; 95% CI 1.78-3.35) were significantly associated with increased Alzheimer's disease risk.
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