Why the study?
Is the ACE gene I/D polymorphism associated with susceptibility to Alzheimer's disease in a Chinese population?
Population
173 Alzheimer's disease patients and 286 normal controls from a Chinese population
Comparison
Angiotensin-converting enzyme gene 287-bp… vs Normal controls / non-bearers of the I allele
Design
Case-control
Authors
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ACE I allele may confer AD susceptibility in Chinese patients; hypothesis-generating and requires replication before clinical consideration.
Is the ACE gene I/D polymorphism associated with susceptibility to Alzheimer's disease in a Chinese population?
The ACE I allele is associated with an increased susceptibility to Alzheimer's disease in a Chinese population, supporting a potential role of ACE polymorphism in AD pathogenesis.
Cheng et al. (2002) studied this question.
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