Key result
ACE promoter A-262T polymorphism linked to ~64% higher Alzheimer's disease risk.
Why the study?
Are ACE gene polymorphisms associated with Alzheimer's disease susceptibility?
Population
Over 3100 individuals from five independent populations evaluated for Alzheimer's disease
Comparison
ACE gene polymorphisms vs Individuals without the specific risk…
Design
Case-control
Authors
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May inform Alzheimer's genetic risk models; leaves open causal role and therapeutic targeting of ACE.
Case-Control (n=3,100)
Yes
Are ACE gene polymorphisms associated with Alzheimer's disease susceptibility?
Odds Ratio: 1.64 (95% CI 1.33–1.94)
p-value: p=2 x 10(-5)
Genetic variations in the ACE gene, particularly the A-262T SNP, are significantly associated with increased susceptibility to Alzheimer's disease, potentially through mechanisms involving beta-amyloid metabolism.
Patrick G. Kehoe (2003) conducted a case-control in Alzheimer's disease (n=3,100). ACE gene polymorphisms (A-262T SNP) vs. Absence of the risk allele was evaluated on Alzheimer's disease (OR 1.64, 95% CI 1.33-1.94, p=2 x 10(-5)). The A-262T single-nucleotide polymorphism in the ACE promoter was significantly associated with Alzheimer's disease (OR 1.64; 95% CI 1.33-1.94; P=2x10^-5).
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