Key result
The II and ID ACE genotypes were associated with increased Alzheimer's disease risk compared to the DD genotype in a meta-analysis (OR for II vs DD 1.36; 95% CI 1.13-1.63; P=0.0002).
Why the study?
Is the ACE gene insertion (I) allele associated with an increased risk of Alzheimer's disease?
Case-Control (n=581)
Is the ACE gene insertion (I) allele associated with an increased risk of Alzheimer's disease?
Odds Ratio: 1.36 (95% CI 1.13–1.63)
p-value: p=0.0002
The ACE gene insertion allele (II and ID genotypes) is significantly associated with an increased risk of Alzheimer's disease.
No takes yet. Share an insight, caveat, or question.
Should not yet alter Alzheimer's risk assessment; leaves open ACE variants' role in genetic models.
Y. Narain (2000) conducted a case-control in Alzheimer's disease (n=581). ACE gene II and ID genotypes vs. ACE gene DD genotype was evaluated on Alzheimer's disease risk (OR 1.36, 95% CI 1.13-1.63, p=0.0002). The II and ID ACE genotypes were associated with increased Alzheimer's disease risk compared to the DD genotype in a meta-analysis (OR for II vs DD 1.36; 95% CI 1.13-1.63; P=0.0002).
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