ABSTRACT 3H-Corticosterone was administered intravenously into two rats. After 80 min the animals were sacrificed and the radioactive material of the different tissues (intestine, liver, kidneys, lungs, adrenals, spleen and the remainder of the animal) was analyzed. Most of this material was found in the intestine and in the liver in a conjugated form and identified as ester-sulphates. This material mainly consisted of hexahydro- and of tetrahydro-derivatives. Corticosterone 21-sulphate was identified in this fraction. 7 to 12% of the radioactivity corresponded to polar conjugated steroids non-hydrolyzed by β-glucuronidase, sulphatase or solvolysis treatment. After hydrolysis of this fraction by the enzymes of succus entericus of Helix pomatia, the radioactive material liberated mainly consisted of hexa- and tetrahydro-corticosterone metabolites.
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Lowy et al. (1969) studied this question.