Key result
Short sleep linked to ~11% higher risk of white matter hyperintensities vs optimal sleep.
Why the study?
The addition of sleep duration to the American Heart Association's Life's Essential 8 highlights the need to understand its association with neuroimaging brain health profiles in asymptomatic middle-aged adults.
Does suboptimal sleep duration worsen neuroimaging brain health profiles in middle-aged individuals without stroke or dementia?
Cohort (n=39,771)
Does suboptimal sleep duration worsen neuroimaging brain health profiles in middle-aged individuals without stroke or dementia?
Odds Ratio: 1.11 (95% CI 1.05–1.18)
p-value: p=<0.001
Suboptimal sleep duration is associated with poorer neuroimaging brain health profiles in asymptomatic middle-aged adults, supporting its inclusion as a key determinant of cardiovascular health.
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Short sleep may raise WMH risk; hypothesis-generating and requires prospective trials before practice change.
Clocchiatti‐Tuozzo et al. (2023) conducted a cohort in Without stroke or dementia (n=39,771). Suboptimal sleep duration (short or long) vs. Optimal sleep duration (7–<9 hours) was evaluated on Presence of white matter hyperintensities (WMHs) (OR 1.11, 95% CI 1.05-1.18, p=<0.001). Compared with optimal sleep, short sleep duration was associated with a higher risk of white matter hyperintensity presence (OR 1.11; 95% CI 1.05-1.18; P<0.001) in middle-aged adults.
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