The morphologic characteristics of brain in humans appear to be sensitive to the effects of both age and sex, and data suggest that these 2 variables may interact over the life span to influence brain size. These morphometrical data can provide a useful context to interpret changes in regional brain structure associated with aging. The corpus callosum is the largest commissure of the brain. It is seen as thick, curved white band on medial surface of sagittaly bisected brain. It is 10 cm long and consist of the rostrum, genu, trunk and splenium. The present study was carried out on 120 females, between the age group of 20-85 years who visited the OPD of Department of radio-diagnosis of SVBP Hospital and NMC Sky Imaging Centre, LLRM Medical College, Meerut. They were studied for various parameters of corpus callosum in mid-sagittal plane by Magnetic Resonance Imaging .Different parts of corpus callosum were compared in adult and senile age groups. Progressive chronological decrease was found with age especially in the region of genu and rostrum, also the maximum width of corpus callosum significantly decreased with increasing age.
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