Detection of circulating dna by counterimmunoelectrophoresis (cie)

Using counterimmunoelectrophoresis, DNA may be detected at concentrations as low as 1.5 μ/ml in plasma and 0.2 μg/ml in serum. Serum, however, was not suitable for this study because DNA was sporadically released into serum during the clotting process. Counterimmunoelectrophoresis is at least ten times more sensitive than simple immunodiffusion in the detection of DNA. DNA was found in plasma in a variety of illnesses which are delineated in this study.