Key result
Short-course cefamandole reduces postoperative chest infections vs. 3-day cephradine after cardiac surgery.
Why the study?
Reducing postoperative chest infections after cardiac operations by optimizing antibiotic prophylaxis was investigated.
Does a short peroperative course of cefamandole reduce postoperative chest infections compared to a 3-day course of cephradine in patients undergoing cardiac operations?
Comparison
Short peroperative course of cefamandole vs 3-day course of cephradine
Design
Randomized controlled trial
Follow-up
Postoperative period
Authors
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Supports short cefamandole prophylaxis to cut chest infections after cardiac surgery; extends RCT evidence favoring optimized perioperative antibiotic duration.
RCT (n=79)
randomly allocated
Does a short peroperative course of cefamandole reduce postoperative chest infections compared to a 3-day course of cephradine in patients undergoing cardiac operations?
A short peroperative course of cefamandole significantly reduces postoperative chest infections compared to a 3-day course of cephradine in patients undergoing cardiac surgery.
Galland et al. (1980) conducted an RCT in cardiac operations (n=79). Cefamandole vs. 3-day course of cephradine was evaluated on postoperative chest infection. A short peroperative course of cefamandole significantly lowered the postoperative chest infection rate compared to a 3-day course of cephradine in 79 patients undergoing cardiac operations.
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