Key result
Post-AMI NT-proBNP strongly predicts 3-month left ventricular remodeling with ~0.89 AUC.
Why the study?
The predictive value of serum NT-proBNP and hs-CRP levels measured early after AMI for subsequent left ventricular remodeling was not well established.
Do serum NT-proBNP and hs-CRP levels at 3 days post-AMI predict left ventricular remodeling at 3 months in patients with first AMI?
Population
106 patients with first AMI after successful reperfusion therapy
Comparison
Serum NT-proBNP vs hs-CRP levels at 3 days after AMI
Design
Observational cohort study
Follow-up
3 months
Authors
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NT-proBNP and hs-CRP at day 3 post-AMI may predict LV remodeling; leaves open incremental utility beyond clinical risk models.
Observational (n=106)
Do serum NT-proBNP and hs-CRP levels at 3 days post-AMI predict left ventricular remodeling at 3 months in patients with first AMI?
Effect estimate: AUC 0.894 for NT-proBNP; AUC 0.825 for hs-CRP
p-value: p=<0.001
Serum NT-proBNP measured 3 days after acute myocardial infarction is a strong predictor of left ventricular remodeling at 3 months.
Hu et al. (2006) conducted an observational in Acute myocardial infarction (n=106). Serum NT-proBNP and hs-CRP levels was evaluated on Left ventricular remodeling (defined as the change rate of LVEDV >20%) (AUC 0.894 for NT-proBNP; AUC 0.825 for hs-CRP, p=<0.001). Serum NT-proBNP (AUC 0.894) and hs-CRP (AUC 0.825) measured 3 days after acute myocardial infarction effectively predicted left ventricular remodeling at 3 months.
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