Why the study?
Does disulfiram cause cytotoxicity in cancer cells with elevated copper levels?
Population
Cancer cells with elevated levels of copper
Design
Review
Key result
Disulfiram, an FDA-approved anti-alcoholism drug, shows potential as an anticancer agent by chelating elevated copper levels in cancer cells to form cytotoxic complexes.
Authors
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Hypothesis-generating for DSF repurposing in cancer; prospective trials needed before clinical adoption.
Does disulfiram cause cytotoxicity in cancer cells with elevated copper levels?
Disulfiram, an FDA-approved drug for alcoholism, is of great interest in cancer research as a potential antitumor agent due to its ability to bind copper and induce cytotoxicity in cancer cells.
Soave et al. (2016) conducted a review in Cancer. Disulfiram was evaluated. Disulfiram, an FDA-approved anti-alcoholism drug, shows potential as an anticancer agent by chelating elevated copper levels in cancer cells to form cytotoxic complexes.
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