Key result
Interatrial conduction time strongly correlates with optimal CRT atrioventricular delays during sensed and paced rhythm.
Why the study?
Optimal atrioventricular delay (AV) programming in CRT devices correlates with interatrial conduction time (IACT), but prospective validation at different heart rates and during sinus rhythm was lacking.
Does interatrial conduction time correlate with optimal atrioventricular timing in patients receiving cardiac resynchronization therapy?
Observational (n=33)
Does interatrial conduction time correlate with optimal atrioventricular timing in patients receiving cardiac resynchronization therapy?
Effect estimate: R = 0.76 (Sinus), R = 0.75 (paced)
p-value: p=<0.0001
Interatrial conduction time is a critical determinant of optimal AV delay for CRT programming, suggesting that heart rate-dependent AV shortening may not be appropriate during atrial pacing.
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May inform AV optimization during CRT implant; leaves open whether this improves outcomes in randomized trials.
Levin et al. (2011) conducted an observational in Cardiac resynchronization therapy (CRT) (n=33). Interatrial conduction time (IACT) was evaluated on Correlation between optimal sensed and paced atrioventricular delays and IACT (R = 0.76 (Sinus), R = 0.75 (paced), p=<0.0001). Interatrial conduction time strongly correlated with optimal sensed (R = 0.76, P < 0.0001) and paced (R = 0.75, P < 0.0001) atrioventricular delays for cardiac resynchronization therapy.