Key result
Higher LC9 score is linked to ~15% lower periodontitis risk per 10-unit increase.
Why the study?
Evidence regarding the utility of Life's Crucial 9 (LC9), integrating cardiovascular and psychological health metrics, in periodontal disease remains limited.
Is a higher Life's Crucial 9 (LC9) score associated with a reduced prevalence of periodontitis in US adults?
Cross-Sectional (n=7,674)
Is a higher Life's Crucial 9 (LC9) score associated with a reduced prevalence of periodontitis in US adults?
Answers are grounded in this paper and cite their sources.
Comprehensive cardiovascular health management, as measured by Life's Crucial 9, is associated with a lower risk of periodontitis, partially mediated by reduced central adiposity and systemic inflammation.
BACKGROUND: Periodontitis, a chronic inflammatory disease, is closely linked to cardiovascular health. While Life's Essential 8 (LE8) evaluates cardiovascular metrics, recent recommendations suggest incorporating psychological health (PHQ-9) to form Life's Crucial 9 (LC9). However, evidence regarding the utility of LC9 in periodontal disease remains limited. METHODS: We analyzed data from 7,674 adults in the 2009-2014 NHANES cycles. LC9 scores were calculated by integrating LE8 and PHQ-9 metrics, then categorized into quartiles. The association between LC9 and periodontitis was examined using weighted logistic regression, restricted cubic spline (RCS), subgroup and WQS analyses. Mediation analysis assessed the roles of central adiposity (ABSI, WWI) and systemic inflammation (SII, SIRI). RESULTS: Higher LC9 scores were associated with lower periodontitis prevalence (29.4% in highest vs. 52.1% in lowest quartile; P < 0.001), with a 15.5% risk reduction per 10-unit increase (OR = 0.845; 95% CI: 0.795-0.897). WQS analysis identified nicotine exposure, sleep health, blood glucose, blood pressure, and depressive symptoms as key contributors. Mediation analysis showed partial effects through WWI (21.617%), ABSI (10.869%), SIRI (7.120%), and SII (5.351%). LC9 did not significantly outperform LE8 in prediction. CONCLUSIONS: Higher LC9 score is linked to reduced periodontitis prevalence and severity, with central adiposity and systemic inflammation partially mediating this relationship. These findings emphasize comprehensive cardiovascular health management may help reduce periodontal disease risk.
No takes yet. Share an insight, caveat, or question.
Hang et al. (2025) conducted a cross-sectional in Periodontitis (n=7,674). Life's Crucial 9 (LC9) score vs. Lower LC9 scores was evaluated on Periodontitis prevalence (per 10-unit increase in LC9 score) (OR 0.845, 95% CI 0.795-0.897, p=<0.001). Higher Life's Crucial 9 (LC9) scores were associated with a lower prevalence of periodontitis, demonstrating a 15.5% risk reduction per 10-unit increase.
Synapse has enriched 10 related papers. Consider them for comparative context: