Key result
Terbinafine exposure combined with increased exercise was associated with the development of rhabdomyolysis (creatine kinase <5000 IU/L) in a 40-year-old female.
Case Report (n=1)
Patients taking terbinafine may be at risk for exercise-induced rhabdomyolysis and should be cautioned regarding exercise intensity.
Terbinafine may predispose to exercise-induced rhabdomyolysis; hypothesis-generating case leaves causality and clinical relevance open.
Introduction. Terbinafine is reported to be associated with rhabdomyolysis. We present a patient taking terbinafine who may have developed exercise-induced rhabdomyolysis. Case Report. A healthy 40-year-old female developed onychomycosis of the right first toe for which she was taking terbinafine. After an increase in her exercise regimen, she began experiencing notable myalgias of the triceps. During outpatient evaluation, the patient was found to have elevated and worsening creatine kinase (CK) and aspartate transaminase. At evaluation in the emergency department, CK was <5000 IU/L and had decreased. She did not have electrolyte abnormalities, kidney injury or kidney failure. Discussion. Patients may be at risk for exercise-induced rhabdomyolysis while on terbinafine and may need to be cautioned regarding the intensity of exercise.
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Bui et al. (2019) conducted a case report in Onychomycosis (n=1). Terbinafine was evaluated on Rhabdomyolysis. Terbinafine exposure combined with increased exercise was associated with the development of rhabdomyolysis (creatine kinase <5000 IU/L) in a 40-year-old female.
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