HLA and 21 hydroxylase deficiency: (congenital and late onset adrenal hyperplasia):in the French population

The close genetic linkage between congenital adrenal hyperplasia (21 OH deficiency) and the HLA B locus has been confirmed in a large series of French families. Two statistically significant, but moderated associations were observed: positive with HLA Bw47 and negative with HLA B8. A strong positive association of late onset with HLA B14 was observed and the results link the trait with HLA loci.