Key result
RELMβ knock-out mice were highly resistant to methionine-choline deficient diet-induced NASH development, exhibiting significantly reduced hepatic lipid accumulation, inflammation, and fibrosis compared to wild-type mice.
Why the study?
Does RELMβ deficiency prevent methionine-choline deficient diet-induced NASH development in mice?
Population
Male C57BL/6 wild-type mice and RELMβ knock-out (KO) mice at 5-6 weeks of age
Comparison
Methionine-choline deficient diet for 8 weeks vs Normal chow diet (NCD) for 8 weeks
Design
Preclinical
Follow-up
8 weeks
Authors
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RELMβ deficiency attenuates NASH in mice; hypothesis-generating for human targeting, should not yet change practice.
Does RELMβ deficiency prevent methionine-choline deficient diet-induced NASH development in mice?
p-value: p=<0.05
RELMβ deficiency protects against MCD diet-induced NASH in mice, suggesting RELMβ as a potential therapeutic target for NASH.
Okubo et al. (2016) studied Non-alcoholic steatohepatitis (NASH). RELMβ knockout vs. Wild-type was evaluated on Development of NASH (hepatic steatosis, inflammation, and fibrosis) (p=<0.05). RELMβ knock-out mice were highly resistant to methionine-choline deficient diet-induced NASH development, exhibiting significantly reduced hepatic lipid accumulation, inflammation, and fibrosis compared to wild-type mice.
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