Distribution reappraisal of peripheral T‐ and NK‐cell lymphoma entities through the French Lymphopath network database

The French National Cancer Institute-labelled Lymphopath network was established to provide real-time expert histopathological review of every newly diagnosed or suspected lymphoma in France.It is composed of expert hematopathologists working across 31 academic institutions, equipped with comprehensive access to immunohistochemistry, fluorescent in situ hybridization (FISH), clonality analysis, and molecular testing (Figure 1A).In 2017, we reported 1 on a review of 36,920 lymphomas registered between 2010 and 2013, including 2049 noncutaneous peripheral T-cell lymphomas (PTCLs).These diagnoses were established according to the criteria of the 2008 WHO classification of lymphoid neoplasms.2 The 2017 revision of the WHO classification 3 introduced significant changes to the classification of PTCLs, which have been largely upheld in the recently updated WHO and ICC classifications.4,5 An important change was the recognition of a broad umbrella category of PTCLs derived from T follicular helper cells (TFH)-now referred to as (nodal) TFH lymphomas (TFHL)-encompassing angioimmunoblastic T-cell lymphoma (AITL) (TFHL, angioimmunoblastic-type), follicular T-cell lymphoma (TFHL, follicular type), and nodal PTCL with TFH phenotype (TFHL, not otherwise specified [NOS]).The latter were classified as PTCL, NOS prior to the 2017 classification.TFHLs share expression of TFH-related antigens as well as clinical features and recurrent mutations.6,7 Another update was the renaming HemaSphere.