Central nervous system penetration and efficacy of targeted therapies used in non-small cell lung cancer and melanoma with brain metastases

Recently, many targeted therapies have been approved for treating brain metastases in non-small cell lung cancer and melanoma patients. In this article, the targeted therapies and their mechanism of action will be reviewed. It will highlight the central nervous system penetration of the targeted therapies. The article will also relate the efficacy of these drugs as seen in clinical trials, which would help guide clinicians when managing these patients.