Key result
Wide regional excision for intraabdominal synovial sarcoma resulted in more than 24 months of disease-free survival in a single patient.
Why the study?
Does wide regional excision improve disease-free survival in patients with intraabdominal synovial sarcoma?
Case Report (n=1)
No
Does wide regional excision improve disease-free survival in patients with intraabdominal synovial sarcoma?
Wide regional excision may allow for prolonged disease-free survival in patients with rare intraabdominal synovial sarcomas.
May support wide excision in rare intraabdominal synovial sarcoma; leaves open confirmation of survival benefit.
BACKGROUND: Reports of primary intraabdominal synovial sarcomas are extremely rare. METHODS: A literature review using PubMed was performed. A retrospective review of the one known case at our institution was completed. RESULTS: Even the most experienced pathologists report that synovial sarcomas can be very difficult to diagnose correctly. One cytogenic abnormality that is common (> 90%) and pathognomonic for synovial sarcoma is a characteristic chromosomal translocation resulting in the SYT/SSX fusion gene. Wide regional excision has been performed for intraabdominal sarcoma, with improved results. Our patient is more than 24 months with no evidence of recurrent or metastatic disease. CONCLUSIONS: The prognosis for patients with intraabdominal synovial sarcoma remains poor. However, wide regional excision may allow for prolonged disease-free survival.
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Eriksen et al. (2010) conducted a case report in Monophasic Synovial Sarcoma of the Small Intestine (n=1). Wide regional excision was evaluated on Recurrent or metastatic disease. Wide regional excision for intraabdominal synovial sarcoma resulted in more than 24 months of disease-free survival in a single patient.
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