Key result
REGICOR-adapted Framingham function accurately predicts 5-year CHD risk, outperforming the original function's overestimation.
Why the study?
The reliability and accuracy of the Framingham CHD risk function adapted to the Spanish population by REGICOR had not been assessed.
Does the REGICOR-adapted Framingham risk function accurately predict 5-year CHD risk in a Spanish population compared to the original Framingham function?
Population
5732 participants aged 35-74 years in Spain
Comparison
REGICOR-adapted Framingham CHD risk function vs original Framingham CHD risk function
Design
5-year follow-up cohort study
Follow-up
5 years
Authors
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Supports local calibration of Framingham scores in Spain; leaves open effects on outcomes or broader generalizability.
Cohort (n=5,732)
Does the REGICOR-adapted Framingham risk function accurately predict 5-year CHD risk in a Spanish population compared to the original Framingham function?
p-value: p=0.078 in men, 0.256 in women
Adapting the Framingham risk function to local population characteristics (REGICOR) provides accurate and reliable 5-year CHD risk prediction in Spain, correcting the overestimation of the original function.
Marrugat et al. (2006) conducted a cohort in Coronary heart disease risk (n=5,732). REGICOR-adapted Framingham risk function vs. Original Framingham risk function was evaluated on Accuracy in estimating the observed 5-year CHD cumulative incidence (p=0.078 in men, 0.256 in women). The REGICOR-adapted Framingham function accurately predicted 5-year CHD risk (goodness of fit p=0.078 in men, p=0.256 in women), whereas the original function overestimated the actual risk (p<0.001).
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