Key result
Elevated adiponectin and reduced nitric oxide metabolites correlate with vascular complications in pediatric T1D.
Why the study?
The association of serum adiponectin and nitric oxide metabolites with vascular complications in children with type 1 diabetes was not well established.
Do serum adiponectin and nitric oxide metabolite levels correlate with the presence of vascular complications in children with type 1 diabetes mellitus?
Case-Control (n=45)
Do serum adiponectin and nitric oxide metabolite levels correlate with the presence of vascular complications in children with type 1 diabetes mellitus?
Serum adiponectin and nitric oxide metabolites may serve as useful biomarkers for predicting and monitoring vascular complications such as nephropathy and neuropathy in children with type 1 diabetes.
Answers are grounded in this paper and cite their sources.
Supports biomarker potential for vascular complications in pediatric type 1 diabetes; leaves open need for prospective validation before clinical use.
Background and Aim: Adiponectin is an adipocytokine secreted from adipose tissue, and plays an important role in type 2 diabetes, obesity, and cardiovascular disease. This study aimed to estimate the concentration of serum adiponectin in type 1 diabetic children and to establish its association with vascular complications of the disease. Materials and Methods: A total of 25 children with type 1 diabetes were enrolled in the study. Another group of 20 healthy children with matched gender and age served as control. The diabetic patients were classified into pre-pubertal and pubertal groups, and according to gender, into male and female groups. Results: The results obtained showed a significant elevation in the serum adiponectin value in diabetic children compared to control. Serum adiponectin level showed a highly significant increase in patients with diabetic nephropathy and neuropathy than those without the complications. On the other hand, no significant increase in serum adiponectin was observed in patients with retinopathy compared to those without retinopathy. Serum nitric acid metabolites showed a significant reduction in type 1 diabetes children compared to the control group. A negative significant correlation was found between serum adiponectin and serum nitric acid metabolites levels, and a positive significant correlation was detected between serum adiponectin and random blood glucose, HbA1C, urinary microalbuminuria, blood urea nitrogen, creatinine, total cholesterol, and LDL in the same patients. Conclusion: In type 1 diabetes, regular estimation of adiponectin with nitric oxide metabolite may be a useful biomarker for early prediction and follow-up of diabetic vascular complications.
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Mohamed Al Saeed (2013) conducted a case-control in Type 1 diabetes mellitus (n=45). Type 1 diabetes mellitus vs. Healthy children was evaluated on Serum adiponectin and nitric oxide metabolites levels. Children with type 1 diabetes had significantly elevated serum adiponectin and reduced nitric oxide metabolites compared to healthy controls, which correlated with vascular complications.
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