Key result
Severe aortic valve sclerosis is linked to ~2.8-fold higher odds of carotid plaque.
Why the study?
A method for qualitative and quantitative measurement of aortic valve sclerosis and its relationship with carotid intima-media thickness in neurologically asymptomatic patients was not established.
Is the severity of aortic valve sclerosis associated with increased carotid intima-media thickness and plaque in neurologically asymptomatic patients?
Cross-Sectional (n=117)
No
Is the severity of aortic valve sclerosis associated with increased carotid intima-media thickness and plaque in neurologically asymptomatic patients?
Odds Ratio: 2.819 (95% CI 1.552–5.119)
Absolute Event Rate: 54.5% vs 19.4%
p-value: p=<0.005
The severity of aortic valve sclerosis is independently associated with increased carotid intima-media thickness and the presence of carotid plaque, suggesting it may serve as a marker for systemic atherosclerosis.
Aortic valve sclerosis severity may mark carotid atherosclerosis but should not change practice; leaves open prospective validation as a risk marker.
Background and Objectives:This study was designed to formulate a method for the qualitative and quantitative measurements of aortic valve sclerosis (AVS) and to assess the relationship between this method and the degree of the carotid intima-media thickness (IMT) in neurologically asymptomatic patients. Subjects and Methods:One hundred and seventeen patients (Male 43%, 57.9±13.1 years of age) were retrospectively studied. Only the rightand non-coronary cusps were analyzed. AVS (cusp thickness of ≥2.0 mm) severities were classified into two groups according to the thickness and presence of the restricted motion of the cusp: mild AVS:AVS of <3.0 mm in one cusp, without restricted motion;severe AVS:AVS (+) in both cusps, AVS (+) and restricted motion in the same cusp, or a thickness ≥3.0 mm. The far wall IMT was measured at its thickest part in the distal 10.0 mm section of the common carotid artery. A protruding lesion with a far wall IMT ≥1.2 mm in the carotid bulb was defined as a plaque. Results:According to the severity of AVS, there was a significant difference in the prevalence of an IMT ≥0.8 mm (38.7 vs. 50.0 vs. 75.8%, p<0.005 for trend) and ≥1.0 mm (14.5 vs. 13.6 vs. 42.4%, p<0.005 for trend), and a plaque (19.4 vs. 36.4 vs. 54.5%, p<0.0005 for trend). The severity of AVS was independently correlated with an IMT ≥0.8 mm and IMT ≥1.0 mm, and with the presence of a plaque from a multiple logistic regression model. Conclusion:There was a significant association between AVS and the carotid IMT/plaque in relation to both in the presence and severity. (Korean Circulation J 2004;34(11):1049-1055)
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Jeon et al. (2004) conducted a cross-sectional in Neurologically asymptomatic patients (n=117). Severity of aortic valve sclerosis vs. No aortic valve sclerosis was evaluated on Presence of carotid plaque (OR 2.819, 95% CI 1.552-5.119, p=<0.005). The severity of aortic valve sclerosis was independently associated with the presence of carotid plaque (OR 2.819) and increased carotid intima-media thickness in neurologically asymptomatic patients.
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