Key result
In pediatric adrenocortical carcinoma, tumor volume >200 cm3 (HR 2.6; 95% CI 1.18-5.70) and distant metastases (HR 8.26; 95% CI 3.49-19.51) were significantly associated with worse progression-free survival.
Population
82 pediatric patients with adrenocortical carcinoma and at least one tumor-related risk factor
Design
Cohort
Follow-up
3 years
Authors
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May aid risk stratification in pediatric adrenocortical carcinoma; hypothesis-generating and requires prospective validation before changing practice.
Observational (n=82)
Yes
Hazard Ratio: 2.6 (95% CI 1.18–5.7)
In pediatric patients with high-risk adrenocortical carcinoma, distant metastases and large tumor volume (>200 cm3) are the strongest independent predictors of poor progression-free and overall survival.
Cecchetto et al. (2016) conducted an observational in Pediatric adrenocortical carcinoma (n=82). Tumor volume >200 cm3 vs. Tumor volume ≤200 cm3 was evaluated on Progression-free survival (PFS) (HR 2.6, 95% CI 1.18-5.70). In pediatric adrenocortical carcinoma, tumor volume >200 cm3 (HR 2.6; 95% CI 1.18-5.70) and distant metastases (HR 8.26; 95% CI 3.49-19.51) were significantly associated with worse progression-free survival.
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