Key result
Having 10 or more genomic imbalances in pediatric adrenocortical cancer was associated with high mortality (85.7% died), whereas all patients with fewer than 10 imbalances remained in remission.
Why the study?
Does the number of genomic imbalances correlate with overall survival in children with adrenocortical cancer?
Population
14 children with adrenocortical cancers (ACC)
Design
Cohort
Follow-up
Median follow-up 72 months for remission group, median…
Authors
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Common gains in pediatric ACC are hypothesis-generating; larger studies needed before prognostic application.
Observational (n=14)
Does the number of genomic imbalances correlate with overall survival in children with adrenocortical cancer?
Absolute Event Rate: 85.7% vs 0%
The number of genomic imbalances detected by comparative genomic hybridisation appears to have predictive value for overall survival in pediatric adrenocortical cancer.
Loncarevic et al. (2008) conducted an observational in Adrenocortical cancer in childhood (n=14). ≥10 genomic imbalances vs. <10 genomic imbalances was evaluated on Death from disease. Having 10 or more genomic imbalances in pediatric adrenocortical cancer was associated with high mortality (85.7% died), whereas all patients with fewer than 10 imbalances remained in remission.
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