Key result
Renin cells harbor a unique set of super-enhancers, including a prominent renin super-enhancer dependent on MED1, that determine their identity and maintain the molecular memory required to restore homeostasis.
Population
Renin cells at various stages of stimulation
Design
Preclinical
Authors
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Offers mechanistic targets for renin dysregulation; leaves open translation from animal models to human hypertension.
This study identifies specific super-enhancers that maintain the molecular memory and identity of renin cells, providing mechanistic insight into how these cells restore homeostasis during physiological stress.
Martínez et al. (2018) studied Renin cell identity and homeostasis. CRISPR/Cas9 targeted deletion of renin super-enhancer regions and Med1 conditional knockout vs. Control cells and wild-type mice was evaluated on Renin mRNA expression and protein release. Renin cells harbor a unique set of super-enhancers, including a prominent renin super-enhancer dependent on MED1, that determine their identity and maintain the molecular memory required to restore homeostasis.
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