Incubation of resibufogenin (1) with cultures of Fusarium lini (BOLLEY) yielded the unknown 12β‐hydroxyresibufogenin (4). The structure of 4 was proved by the degradation of its diacetyl derivative 5 to methyl 3β,12β‐diacetoxy‐l4β, 15β‐epoxy‐5β, 14β, 17αH‐etianate (9) which was identical with the degradation product obtained from 14β,15β‐epoxy‐14‐anhydro‐digoxigenin diacetate (7). The latter was prepared from di‐O‐acetyl digoxigenin (8). Incubation of 14β, 15β‐epoxy‐14‐anhydro‐digitoxigenin (2) with F. lini led to the 12β‐hydroxy derivative 6, its diacetate being identical with 7. LiAlH4‐reduction of both the epoxyester 9 and the hydroxyester 12 derived from digoxigenin gave the same tetrol 10.
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Schüpbach et al. (1964) studied this question.
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