Key result
NFATc 1-4 proteins show promise as early clinical biomarkers for pathological cardiac hypertrophy and CVD.
Why the study?
The expression of NFATc family genes in congenital heart diseases with valvular defects and arterial hypertension is adaptive and stress-induced, suggesting their potential as early clinical markers for cardiovascular disorder development.
Can NFATc 1-4 gene expression serve as a diagnostic and prognostic marker in patients with congenital valvular diseases and myocardial hypertrophy?
Can NFATc 1-4 gene expression serve as a diagnostic and prognostic marker in patients with congenital valvular diseases and myocardial hypertrophy?
NFATc 1-4 gene expression may serve as a promising biomarker for early clinical prediction of cardiovascular disorders in congenital heart disease and hypertension.
Answers are grounded in this paper and cite their sources.
NFATc proteins merit validation as hypertrophy markers; leaves open their adoption for early cardiovascular prediction.
Aim. The nuclear factor of activated T-cells (NFATc 1-4) family gene expression against the background of cardiovascular disorders, accompanying both congenital heart diseases (mainly ones involving valvular defects) and arterial hypertension, is adaptive and stress-induced by the respective hemodynamic stress.Results. In this regard, given the fact that these proteins play a critical role in both formation of the cardiac structures and, at the same time, development of pathological myocardial and vascular wall hypertrophy, they, along with the signaling activating factors, can be regarded as quite promising biological markers for early clinical prediction of development of the cardiovascular disorders in patients with certain congenital heart diseases (especially with valve anomalies) or hypertension.
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Каmеnshchyk et al. (2015) conducted a review in Congenital heart diseases and myocardial hypertrophy. NFATC gene expression and polymorphism was evaluated. NFATc 1-4 proteins play a critical role in cardiac structure formation and pathological hypertrophy, serving as promising biological markers for early clinical prediction of cardiovascular disorders.
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