Key result
Non-invasive ventilation was not significantly associated with improved day-8 mortality in elderly patients with acute heart failure (OR 0.50; 95% CI 0.17-1.45; P=0.20).
Why the study?
The role and prescription patterns of non-invasive ventilation in very old patients with acute heart failure admitted to Emergency Departments are poorly defined.
Does non-invasive ventilation improve day-8 mortality in patients over 75 years old admitted to the Emergency Department for acute heart failure?
Observational (n=213)
No
Does non-invasive ventilation improve day-8 mortality in patients over 75 years old admitted to the Emergency Department for acute heart failure?
Odds Ratio: 0.5 (95% CI 0.17–1.45)
p-value: p=0.20
In elderly patients (>75 years) presenting to the ED with acute heart failure, non-invasive ventilation is uncommonly prescribed and does not appear to be associated with improved day-8 mortality.
Should not yet change NIV use in elderly ED patients with acute HF; leaves open efficacy and supports randomized trials.
Acute Heart Failure (AHF) is a main cause of acute respiratory failure for patients admitted to Emergency Departments (ED). Non-invasive ventilation (NIV) is recommended as a first-line therapy for acute respiratory failure in patients with AHF, but its role in the ED for very old patients is poorly defined. The primary goal of this study was to estimate NIV prescription for older patients with AHF. Secondary goals were to identify determinants of NIV prescription, and to measure the association between NIV and day-8 outcomes in elderly patients. Retrospective observational study at the ED of the University Hospital of Poitiers, France, assessing patients over 75 years old with AHF who had indication for NIV. A total of 213 patients were included and NIV was only performed as BiPAP and in 17.4%. Patients who received NIV were younger (median [interquartile range], 85 [81–90] versus 87 [84–92] years; P = 0.045) and had lower pH values (7.29 [7.21–7.37] versus 7.41 [7.34–7.45]; P < 0.001) than others. NIV prescription was independently associated with Age, SpO2, pH and pCO2. NIV was not associated with a better mortality rate (OR 0.50 [0.17–1.45]; P = 0.20). In our ED, NIV for AHF is uncommonly performed in the elderly and seems not associated with better outcome in this population regardless of comorbidities and autonomy. L’insuffisance cardiaque aiguë (ICA) est une des principales causes de détresse respiratoire aigüe (DRA) chez les patients consultant aux urgences. La ventilation non-invasive (VNI) est un traitement recommandé pour les patients présentant une DRA secondaire à une ICA. Cependant, son intérêt dans la prise en charge des patients très âgés a été peu évalué. L’objectif principal de cette étude a été d’estimer le taux de prescription de VNI pour les patients très âgés avec ICA. Les objectifs secondaires ont été d’identifier les déterminants de la prescription d’une VNI et d’estimer l’association entre la VNI et le pronostic à 8 jours des patients très âgés. Etude observationnelle rétrospective conduite aux urgences du CHU de Poitiers, évaluant les patients de plus de 75 ans avec ICA avec indication d’une VNI. Deux cent treize patients ont été inclus et une VNI a été prescrites par BiPAP et pour 17.4 %. Les patients ayant reçu une VNI était plus jeune (médiane [interquartile], 85 [91–90] versus 87 [84–92] ans ; p = 0,045) et avait des valeurs de pH plus faible. (7,29 [7,21–7,37] versus 7,41 [7,34–7,41] ; p < 0,001). La prescription d’une VNI était associée à l’âge, la SpO2, le pH et la pCO2. Elle n’a pas été associé avec une amélioration de la mortalité (OR 0,50 [0,17–1,45] ; p = 0,20). Dans notre service d’urgence, la VNI pour ICA a été peu prescrite aux patients âgés et ne semble pas être associé à une amélioration du pronostic, indépendamment des comorbidités et de l’autonomie.
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Gillet et al. (2019) conducted an observational in Acute Heart Failure (n=213). Non-invasive ventilation (NIV) vs. No non-invasive ventilation was evaluated on Day-8 mortality (OR 0.50, 95% CI 0.17-1.45, p=0.20). Non-invasive ventilation was not significantly associated with improved day-8 mortality in elderly patients with acute heart failure (OR 0.50; 95% CI 0.17-1.45; P=0.20).
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