Key result
Reduced psoas muscle mass index is linked to ~230% higher cardiovascular event risk.
Why the study?
The prognostic value of muscle wasting, defined by psoas muscle mass index, in patients with non‒ST‐segment‒elevation myocardial infarction was not established.
Does reduced psoas muscle mass index predict cardiovascular events in patients with non-ST-segment-elevation myocardial infarction?
Population
132 consecutive patients with non‒ST‐segment‒elevation myocardial infarction
Comparison
Reduced PMI (<772 mm2/m2) vs preserved PMI (≥772 mm2/m2)
Design
Prospective observational study
Follow-up
Median 2.4 years (interquartile range, 1.1–4.0 years)
Authors
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May inform NSTEMI risk stratification; leaves open whether muscle-targeted interventions improve outcomes.
Observational (n=132)
Does reduced psoas muscle mass index predict cardiovascular events in patients with non-ST-segment-elevation myocardial infarction?
Hazard Ratio: 3.3 (95% CI 1.7–6.4)
Absolute Event Rate: 48% vs 21%
p-value: p=<0.001
Muscle wasting, defined by a reduced psoas muscle mass index, is a strong independent predictor of adverse cardiovascular outcomes in patients with NSTEMI.
Matsumoto et al. (2020) conducted an observational in non-ST-segment-elevation myocardial infarction (n=132). Reduced psoas muscle mass index (PMI <772 mm2/m2) vs. Preserved psoas muscle mass index (PMI ≥772 mm2/m2) was evaluated on Incidence of cardiovascular events including cardiovascular deaths, non-fatal myocardial infarction, or non-fatal stroke (HR 3.30, 95% CI 1.70-6.40, p=<0.001). Reduced psoas muscle mass index was associated with a significantly higher risk of cardiovascular events compared to preserved index (48% vs 21%; HR 3.30; 95% CI 1.70-6.40; P<0.001).
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